FAT (gene)

FAT tumor suppressor homolog 1 (Drosophila)

Identifiers

FAT1; CDHF7; CDHR8; FAT; ME5; hFat1

External IDs

OMIM: 600976 MGI: 109168 HomoloGene: 66302 GeneCards: FAT1 Gene

Gene Ontology
Molecular function	• calcium ion binding • protein binding
Cellular component	• nucleus • cytoplasm • plasma membrane • integral to plasma membrane • cell-cell junction • perinuclear region of cytoplasm
Biological process	• actin filament organization • cell adhesion • homophilic cell adhesion • establishment or maintenance of cell polarity • cell-cell signaling • anatomical structure morphogenesis • cell-cell adhesion • cell migration
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
187.51 – 187.65 Mb

Chr 8:
46.04 – 46.14 Mb

PubMed search

[1]

[2]

Protocadherin Fat 1 is a protein that in humans is encoded by the FAT1 gene.^[1]^[2]

This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described.^[2]

References

^ Dunne J, Hanby AM, Poulsom R, Jones TA, Sheer D, Chin WG, Da SM, Zhao Q, Beverley PC, Owen MJ (Mar 1996). "Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule". Genomics 30 (2): 207–23. doi:10.1006/geno.1995.9884. PMID 8586420.
^ ^a ^b "Entrez Gene: FAT FAT tumor suppressor homolog 1 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2195.

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Matsuyoshi N, Tanaka T, Toda K, Imamura S (1997). "Identification of novel cadherins expressed in human melanoma cells.". J. Invest. Dermatol. 108 (6): 908–13. doi:10.1111/1523-1747.ep12292703. PMID 9182820.
Matsuyoshi N, Imamura S (1997). "Multiple cadherins are expressed in human fibroblasts.". Biochem. Biophys. Res. Commun. 235 (2): 355–8. doi:10.1006/bbrc.1997.6707. PMID 9199196.
Dias Neto E, Correa RG, Verjovski-Almeida S et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=16267.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Brandenberger R, Wei H, Zhang S et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Tanoue T, Takeichi M (2004). "Mammalian Fat1 cadherin regulates actin dynamics and cell–cell contact". J. Cell Biol. 165 (4): 517–28. doi:10.1083/jcb.200403006. PMC 2172355. PMID 15148305. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172355.
Suzuki Y, Yamashita R, Shirota M et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=515316.
Wu Q (2005). "Comparative Genomics and Diversifying Selection of the Clustered Vertebrate Protocadherin Genes". Genetics 169 (4): 2179–88. doi:10.1534/genetics.104.037606. PMC 1449604. PMID 15744052. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1449604.
Magg T, Schreiner D, Solis GP et al. (2005). "Processing of the human protocadherin Fat1 and translocation of its cytoplasmic domain to the nucleus". Exp. Cell Res. 307 (1): 100–8. doi:10.1016/j.yexcr.2005.03.006. PMID 15922730.
Blair IP, Chetcuti AF, Badenhop RF et al. (2006). "Positional cloning, association analysis and expression studies provide convergent evidence that the cadherin gene FAT contains a bipolar disorder susceptibility allele". Mol. Psychiatry 11 (4): 372–83. doi:10.1038/sj.mp.4001784. PMID 16402135.
Schreiner D, Müller K, Hofer HW (2006). "The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins". FEBS Lett. 580 (22): 5295–300. doi:10.1016/j.febslet.2006.08.079. PMID 16979624.
Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Nakaya K, Yamagata HD, Arita N et al. (2007). "Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array". Oncogene 26 (36): 5300–8. doi:10.1038/sj.onc.1210330. PMID 17325662.
Braun GS, Kretzler M, Heider T et al. (2007). "Differentially spliced isoforms of FAT1 are asymmetrically distributed within migrating cells". J. Biol. Chem. 282 (31): 22823–33. doi:10.1074/jbc.M701758200. PMID 17500054.

FAT (gene)

References

Further reading